Miami CTSI

June 20: Translational Approaches Targeting the Immune Microenvironment of Hepatocellular Carcinoma

06.07.2016

Please join us Monday, June 20, from 5 to 6 p.m. for a guest lecture on Translational Approaches Targeting the Immune Microenvironment of Hepatocellular Carcinoma and Implications for Antitumor Therapy presented by Valerie Chew, Ph.D., Assistant Professor at Duke-National University of Singapore Medical School and SingHealth Translational Immunology and Inflammation Centre. The lecture will take place at the Don Soffer Clinical Research Center (formerly CRB), room 1080A.

For more information, please contact Emmanuel Thomas M.D., Ph.D., Ethomas1@med.miami.edu or 305-243-2895.

ABSTRACT

Hepatocellular carcinoma (HCC) is an aggressive cancer with limited treatment options targeting specific molecular pathways. Despite recent success in cancer therapies, the dynamic relations between tumor-microenvironment (TME) and the systemic immune response remains elusive.

Dr. Chew and her team have previously identified a 14 immune-gene signature that predicts patient survival in a total of 155 HCC patients from Singapore, Hong Kong and Zurich, irrespective of patient ethnicity and disease aetiology. Given the critical role of TME in tumor control, they integrated three multidimensional technologies: Time of Flight Mass Cytometry (CyTOF), Next Generation Sequencing (NGS) and NanoString technologies for deeper analysis of TME in their current study.

They aim to interrogate the “cancer immune-gradient” which encompasses the tumor (T) microenvironment, its adjacent non-tumor liver tissues (NT) and peripheral blood (PB).

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